Alex Graham was an energetic teenager and epitome of health. Amazingly she never contracted the typical childhood illnesses, but in 1997 all that was to change. One early fall day Alex came home from the mall complaining of pain in her knee. Three months later, at the age of 16, she was diagnosed with bone cancer. Her world and the world of those she loved would never be the same. Over the course of the next year, Alex did not get the miracle she wanted most, but her life and her selfless wish left the world a better place.

When One Door Closes shows us the powerful influence one person can unleash in the face of tragedy. A teenage girl fighting osteogenic sarcoma, amputation of her leg and partial loss of lung defines herself by who she is and the choices she makes, not by her illness. In their own words, family, friends, medical experts, caregivers and a rock star tell us how Alexandra (Alex) Graham opened doors and made a difference in their lives. Even individuals who never met Alex share how their lives have taken on new meaning because of Alex's wish and legacy. This factual account will bring understanding and perspective to those directly or indirectly facing a life-threatening illness particularly in cases where the patient is a teenager.